Cart
sales@molnova.com
UK 383367
CAS No. 348622-88-8
UK 383367( UK-383367, UK 383367, UK383367 )
Catalog No. M18461 CAS No. 348622-88-8
UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | Get Quote |
|
| 10MG | 61 | Get Quote |
|
| 25MG | 102 | Get Quote |
|
| 100MG | 529 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameUK 383367
-
NoteResearch use only, not for human use.
-
Brief DescriptionUK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
-
DescriptionUK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.
-
In Vitro——
-
In Vivo——
-
SynonymsUK-383367, UK 383367, UK383367
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
RecptorProcollagen C proteinase
-
Research AreaOthers-Field
-
Indication——
Chemical Information
-
CAS Number348622-88-8
-
Formula Weight324.38
-
Molecular FormulaC15H24N4O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 65 mg/mL (200.38 mM)
-
SMILESNC(=O)C1=NOC(=N1)[C@H](CCCC1CCCCC1)CC(=O)NO
-
Chemical Name(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Fish PV, et al. J Med Chem, 2007, 50(15), 3442-3456.
molnova catalog
related products
-
DAMGO
DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
-
PH797804
PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.
-
(-)-Bornyl acetate
(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity.
