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UK 383367
CAS No. 348622-88-8
UK 383367( UK-383367, UK 383367, UK383367 )
Catalog No. M18461 CAS No. 348622-88-8
UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | Get Quote |
|
| 10MG | 61 | Get Quote |
|
| 25MG | 102 | Get Quote |
|
| 100MG | 529 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameUK 383367
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NoteResearch use only, not for human use.
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Brief DescriptionUK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
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DescriptionUK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.
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In Vitro——
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In Vivo——
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SynonymsUK-383367, UK 383367, UK383367
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorProcollagen C proteinase
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number348622-88-8
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Formula Weight324.38
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Molecular FormulaC15H24N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 65 mg/mL (200.38 mM)
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SMILESNC(=O)C1=NOC(=N1)[C@H](CCCC1CCCCC1)CC(=O)NO
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Chemical Name(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fish PV, et al. J Med Chem, 2007, 50(15), 3442-3456.
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